The Late Phase of the Immediate Wheal and Flare Skin Reaction ITS DEPENDENCE UPON IgE ANTIBODIES GRAHAM
نویسنده
چکیده
cent staining did not show deposition of immunoglobulins or complement components, except IgM in 2 of 15 and C3 in 1 of 15 patients. This finding indicates that the late phase does not depend on the deposition of imReceived for publication 18 August 1975 and in revised form 22 March 1976. mune complexes. The results of the study suggest that IgE-allergen interaction on the surfaces of mast cells or on infiltrating basophils causes both immediate and late cutaneous responses.
منابع مشابه
The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
IgE antibodies are usually thought to induce only immediate skin reactions. We have shown that the intradermal injection of a number of different allergens can produce a prolonged inflammatory reaction after the immediate wheal and flare in most sensitive subjects. This late inflammatory response occurs 6-12 h after challenge and is characterized by diffuse edema, erythema, pruritus, and heat. ...
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تاریخ انتشار 2013